Apigenin, a natural flavonoid, promotes autophagy and ferroptosis in human endometrial carcinoma (EC) Ishikawa cells <i>in vitro</i> and <i>in vivo</i>

Apigenin, a natural flavonoid has been reported against variety of cancer types. However, it is unclear whether apigenin can promote autophagy and ferroptosis in Ishikawa cells. There are few reports on the mechanism endometrial We found that iron accumulation, lipid peroxidation, GSH consumption, p62, HMOX1, ferritin were increased, while, SLC7A11 GPX4 decreased. Fer-1, an iron-death inhibitor could reverse effects On other hand, via up-regulating Beclin 1, ULK1, ATG5, ATG13, LC3B down-regulating AMPK, mTOR, P70S6K, ATG4. Furthermore, inhibit tumor tissue proliferation restrict growth in vivo.